<html xmlns="http://www.llu.edu/bsl"> <head> <title>Hodgkin Huxley Nerve Action Potential</title> </head> <body bgcolor=""> <h1 align="center"> <b>Hodgkin Huxley Nerve Action Potential</b> </h1> <h2>Description: </h2> <p>Can be used in both current-clamp and voltage-clamp modes.</p> <h2>Version: </h2> <p>Last modified 2002-11-26.</p> <h2>Authors: </h2> <p>J.M. Kootsey, G. McAuley.</p> <h2>Equations:</h2> <h3>State:</h3> <p><img src="hodhuxS.jpg" alt="State"/> </p> <h3>Assigned:</h3> <p><img src="hodhuxA.jpg" alt="Assigned"/> </p> <br/> <h2>Parameters:</h2> <table border="1" cellspacing="5" cellpadding="10"> <tr bgcolor="white"> <th>Name</th> <th>Units</th> <th>Default Value</th> <th>Description</th> </tr> <tr> <td>gbarNa</td> <td>mS/cm2</td> <td align="right">120</td> <td>Maximum sodium conductance</td> </tr> <tr> <td>gbarK</td> <td>mS/cm2</td> <td align="right">36</td> <td>Maximum potassium conductance</td> </tr> <tr> <td>gbarl</td> <td>mS/cm2</td> <td align="right">0.3</td> <td>Leak conductance</td> </tr> <tr> <td>ENa</td> <td>mV</td> <td align="right">55.1092</td> <td>Sodium equilibrium potential</td> </tr> <tr> <td>EK</td> <td>mV</td> <td align="right">-72.1483</td> <td>Potassium equilibrium potential</td> </tr> <tr> <td>El</td> <td>mV</td> <td align="right">-49.387</td> <td>Leak equilibrium potential</td> </tr> <tr> <td>stim1Amp</td> <td>uA</td> <td align="right">20</td> <td>Amplitude of first stimulus pulse</td> </tr> <tr> <td>stim1Dur</td> <td>mSec</td> <td align="right">0.5</td> <td>Duration of first stimulus pulse</td> </tr> <tr> <td>stim1Delay</td> <td>mSec</td> <td align="right">0.0</td> <td>Delay of first stimulus pulse</td> </tr> <tr> <td>stim2Amp</td> <td>uA</td> <td align="right">20</td> <td>Amplitude of second stimulus pulse</td> </tr> <tr> <td>stim2Dur</td> <td>mSec</td> <td align="right">0.5</td> <td>Duration of second stimulus pulse</td> </tr> <tr> <td>stim2Delay</td> <td>mSec</td> <td align="right">20</td> <td>Delay of second stimulus pulse</td> </tr> </table> <br/> <h2>Independent Variable:</h2> <table border="1" cellspacing="5" cellpadding="10"> <tr bgcolor="white"> <th>Name</th> <th>Units</th> <th>Initial Value</th> <th>Description</th> </tr> <tr> <td>time</td> <td>mSec</td> <td align="right">0</td> <td>time</td> </tr> </table> <br/> <h2>State Variables:</h2> <table border="1" cellspacing="5" cellpadding="10"> <tr bgcolor="white"> <th>Name</th> <th>Units</th> <th>Initial Value</th> <th>Description</th> </tr> <tr> <td>V</td> <td>mV</td> <td align="right">-60</td> <td>transmembrane potantial</td> </tr> <tr> <td>m</td> <td>1</td> <td align="right">0.052678</td> <td>Na+ activation variable</td> </tr> <tr> <td>h</td> <td>1</td> <td align="right">0.59758</td> <td>Na+ inactivation variable</td> </tr> <tr> <td>n</td> <td>1</td> <td align="right">0.31704</td> <td>K+ activation variable</td> </tr> </table> <br/> <h2>Assigned Variables:</h2> <table border="1" cellspacing="5" cellpadding="10"> <tr bgcolor="white"> <th>Name</th> <th>Units</th> <th>Initial Value</th> <th>Description</th> </tr> <tr> <td>INa</td> <td>uA/cm2</td> <td align="right"></td> <td>Sodium current</td> </tr> <tr> <td>IK</td> <td>uA/cm2</td> <td align="right"></td> <td>Potassium current</td> </tr> <tr> <td>Il</td> <td>uA/cm2</td> <td align="right"></td> <td>Leak current</td> </tr> <tr> <td>Itotal</td> <td>uA/cm2</td> <td align="right"></td> <td>Total ionic current</td> </tr> <tr> <td>gNa</td> <td>mS/cm2</td> <td align="right"></td> <td>Sodium conductance</td> </tr> <tr> <td>gK</td> <td>mS/cm2</td> <td align="right"></td> <td>Potassium conductance</td> </tr> </table> <br/> <h2>References:</h2>J. Physiol. (London) 117:500-544 (1952)</body> <h5 align="center"> Loma Linda University,2003.All rights reserved.</h5> </html>