Pulmonary Nitric Oxide Exchange

Description:

     Model of airway NO exchange (see references for assumptions).

Version:

     1.0.0.0, last modified 2004-4-12.

Authors:

     J.M. Kootsey, G. McAuley.

Equations:

     State:

     State

     Assigned:

     Assigned


Parameters:

NameUnitsDefault ValueDescription
lcm10The length of the airway
Cwppb150NO concentration in the airway wall
Calppb5Alveolar NO concentration
Qdotml/s30Exhalation rate
Dwpl/s/ppb6.8Airway NO diffusing capacity

Independent Variable:

NameUnitsInitial ValueDescription
xcm0Distance along airway

State Variables:

NameUnitsInitial ValueDescription
CappbassignedNO airway concentration

Assigned Variables:

NameUnitsInitial ValueDescription
Vdotppb ml/s assignedNO volume flow rate (Ca * Qdot)
CeppbassignedAnalytical NO exhalation concentration Ca(x = l)
Vdot_Eppb ml/sassignedAnalytical NO volume flow rate at exhalation (Ce * Qdot)
a_Vdot_Eppb ml/s assignedLinear approximation to Vdot_E (Dw << Qdot)

References:

     1) Hogman M, Drca N, Ehrstedt C, and Merilainen P. Exhaled nitric oxide partitioned into alveolar, lower airways and nasal contributions. Respir Med 94: 985-991, 2000.

     2) Pietropaoli AP, Perillo IB, Torres A, Perkins PT, Frasier LM, Utell MJ, Frampton MW, and Hyde RW. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J Appl Physiol 87: 1532-1542, 1999.

     3) Silkoff PE, Sylvester JT, Zamel N, and Permutt S. Airway nitric oxide diffusion in asthma. Role in pulmonary function and bronchial responsiveness. Am J Respir Crit Care Med 161: 1218-1228, 2000.

     4) Tsoukias NM and George SC. A two-compartment model of pulmonary nitric oxide exchange dynamics. J Appl Physiol 85: 653-666, 1998.



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